Pgap1^oto
Radiation induced Allele Detail

Summary

• Symbol: Pgap1^oto
• Name: post-GPI attachment to proteins 1; otocephaly
• MGI ID: MGI:1856621
• Synonyms: oto^xray
• Gene: Pgap1 Location: Chr1:54512159-54596843 bp, - strand Genetic Position: Chr1, 27.25 cM
• Alliance: Pgap1^oto page

Forebrain defects in Pgap1^oto/Pgap1^oto, Pgap1^oto/Pgap1^tm1Asp, and Pgap1^tm1Asp/Pgap1^tm1Asp embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: STOCK In(1)1Rk/J

Mutation description

• Allele Type: Radiation induced
• Mutation: Undefined
• Mutation details: While no mutations could be identified in cDNA sequence, northern blot analysis confirmed reduced expression of Pgap1 protein in adult mutant tissue and E10.5 embryos. mRNA length is normal indicating the mutational event disrupts a regulatory region, attenuating transcription. (J:151594)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	41 assay results
In Structures Affected by this Mutation:	26 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pgap1 Mutation: 53 strains or lines available

Notes

This mutation was probably induced by X irradiation of a male homozygous for the Chr 1 inversion In(1)1Rk. Segregation among descendants of this male showed that oto is either within or closely linked to the inversion.

References

• Original: J:7938 Juriloff DM, et al., Genetic and developmental studies of a new mouse mutation that produces otocephaly. J Craniofac Genet Dev Biol. 1985;5(2):121-45
• All: 4 reference(s)