Paf
Spontaneous Allele Detail

Summary

• Symbol: Paf
• Name: patchy fur
• MGI ID: MGI:1856622
• Synonyms: In(XPAR)^Paf, X^Paf
• Gene: Paf Location: unknown Genetic Position: ChrX, Syntenic
• Alliance: Paf page

A Paf/Paf⁺ female

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C3H/HeSn-bc^3J

Mutation description

• Allele Type: Spontaneous
• Mutation: Inversion
• Mutation details: This mutation comprises an inversion of an X chromosome segment with breakpoints distal to Amel and proximal to the PAR marker DXYHgu1. The mutation in this allele is within a ~0.2 cM interval that includes the boundary of the pseudoautosomal region (PAR), a sequence common to the X and Y chromosomes. As a consequence X-Y nondisjunction occurs in hemizygous males, resulting in XO and XXY progeny. (J:10459, J:52077)
• Inheritance: Semidominant

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Paf Mutation: 1 strain or line available

References

• Original: J:10459 Lane PW, et al., Patchy fur (Paf), a semidominant X-linked gene associated with a high level of X-Y nondisjunction in male mice. J Hered. 1990 Jan-Feb;81(1):43-50
• All: 23 reference(s)