ptd
Allele Detail

Summary

• Symbol: ptd
• Name: palate-tail-digits abnormality
• MGI ID: MGI:1856624
• Gene: ptd Location: unknown Genetic Position: ChrX, Syntenic
• Alliance: ptd page

Mutation origin

• Strain of Origin: (BALB/c x SJL)F1 x BALB/c

Mutation description

• Allele Type: Not Applicable
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any ptd Mutation: 0 strains or lines available

Notes

This mutation affecting morphogenesis appeared in a male mouse obtained from a blastomere-enucleated blastomere fusion experiment. Males hemizygous and females homozygous for the allele exhibit malformations of the tail, polydactyly in the hind feet, and, in 60% of cases, cleft palate. Other skeletal defects may also occur. More than 80% of expected hemizygous males, and more than 90% of expected homozygous females, die during gestation or soon after birth. The penetrance of the this mutation is also incomplete. Survivors are fertile. The sex-linked mode of inheritance and crosses involving Eda and Plp placed the ptd locus on the X chromosome (J:10812).

References

• Original: J:10812 Barra J, An X-linked recessive mutation producing cleft palate, crooked tail, and polydactyly in mice. J Hered. 1990 Sep-Oct;81(5):388-92
• All: 2 reference(s)