Otop1^tlt
Spontaneous Allele Detail

Summary

• Symbol: Otop1^tlt
• Name: otopetrin 1; tilted
• MGI ID: MGI:1856638
• Synonyms: tilted head, tlt
• Gene: Otop1 Location: Chr5:38434748-38461560 bp, + strand Genetic Position: Chr5, 20.35 cM
• Alliance: Otop1^tlt page

Mutation origin

• Strain of Origin: STOCK Oca2^p-6H/Oca2^p-d

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: The mutation in the tlt mouse has been identified as a C-to-A transversion at coding nucleotide 452 in the third exon of the gene. This results in a alanine to glutamic acid change at amino acid position 151 (p.A151E). (J:82639)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Otop1 Mutation: 41 strains or lines available

References

• Original: J:30803 Lane PW, Tilted (tlt). Mouse News Lett. 1986;75:28
• All: 17 reference(s)