Rab27a^ash
Spontaneous Allele Detail

Summary

• Symbol: Rab27a^ash
• Name: RAB27A, member RAS oncogene family; ashen
• MGI ID: MGI:1856656
• Synonyms: ash
• Gene: Rab27a Location: Chr9:72952136-73004911 bp, + strand Genetic Position: Chr9, 40.08 cM
• Alliance: Rab27a^ash page

Rab27a^ash/Rab27a^ash and Mreg^dsuRab27a^ash/Mreg^dsu Rab27a^ash

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C3H/HeSn

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: Sequence analysis of the coding region revealed an A-to-T transversion in the third base pair of the splice donor site downstream of exon 4. This results in activation of two cryptic downstream splice donor sites and the addition of intronic sequence into mis-spliced Rab27a mRNA. (J:63231)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Rab27a Mutation: 146 strains or lines available

References

• Original: J:4458 Lane PW, et al., Ashen, a new color mutation on chromosome 9 of the mouse. J Hered. 1979;70(2):133-135
• All: 65 reference(s)