Acd^acd
Spontaneous Allele Detail

Summary

• Symbol: Acd^acd
• Name: adrenocortical dysplasia
• MGI ID: MGI:1856658
• Synonyms: acd
• Gene: Acd Location: Chr8:106424789-106427748 bp, - strand Genetic Position: Chr8, 53.04 cM
• Alliance: Acd^acd page

Mutation origin

• Strain of Origin: DW/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: This spontaneous mutation arose at The Jackson Laboratory in 1985. A point mutation (G to A) in the +5 position of the splice donor site in the third intron of the gene was revealed by DNA sequence analysis. RT-PCR analysis showed that aberrant transcripts were expressed from this allele, all of which are predicted to alter the reading frame of the protein. (J:95686)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	29 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Acd^acd

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Acd Mutation: 22 strains or lines available

Notes

This mutation occurred in a subline of DW/J that lacks the Pou1f1^dw mutation. J:18027

References

• Original: J:14144 Sweet HO, et al., Adrenocortical dysplasia (acd). Mouse News Lett. 1988;81:69
• All: 8 reference(s)