Abl1^m1
Targeted Allele Detail

Summary

• Symbol: Abl1^m1
• Name: c-abl oncogene 1, non-receptor tyrosine kinase; mutation 1
• MGI ID: MGI:1856663
• Synonyms: abl^m1
• Gene: Abl1 Location: Chr2:31578388-31694239 bp, + strand Genetic Position: Chr2, 21.86 cM, cytoband B
• Alliance: Abl1^m1 page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:72519
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A promoterless neomycin resistance gene was inserted into coding sequences corresponding to the carboxy terminus of the protein, downstream of the tyrosine kinase domain and nuclear targeting sequences. This allele expresses a protein with a functional kinase domain but a disrupted carboxy terminus containing the DNA and actin binding domains. (J:72518)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Abl1 Mutation: 93 strains or lines available

References

• Original: J:72519 Schwartzberg PL, et al., Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells. Science. 1989 Nov 10;246(4931):799-803
• All: 10 reference(s)