Srrm4^bv
Spontaneous Allele Detail

Summary

• Symbol: Srrm4^bv
• Name: serine/arginine repetitive matrix 4; Bronx waltzer
• MGI ID: MGI:1856676
• Synonyms: flopsy, fp
• Gene: Srrm4 Location: Chr5:116577334-116729876 bp, - strand Genetic Position: Chr5, 56.45 cM, cytoband F
• Alliance: Srrm4^bv page

The abnormal inner hair cell phenotype of Srrm4^bv/Srrm4^bv mice is rescued by hair-cell targeted expression of the Tg(Myo7a-Srrm4)#Bban transgene

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: Not Specified

Mutation description

Allele Type: Spontaneous Mutation: Intragenic deletion Mutation details: A spontaneous one base pair deletion in an intron that results in the deletion of some of the last intron and all of the last exon (2710 bp) but retention of the polyadenylation sequence. Western blot analysis confirmed reduced expression of a truncated protein. (J:193641) Inheritance: Recessive

Schematic of the spontaneous deletion mutation in the Srrm4^bv allele

Expression

In Mice Carrying this Mutation:	418 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Srrm4 Mutation: 40 strains or lines available

Notes

This mutation was found in a stock at Albert Einstein College of Medicine.

References

• Original: J:28901 Gluecksohn Waelsch S, Research News. Mouse News Lett. 1969;41:16
• All: 26 reference(s)