Rpl24^Bst
Spontaneous Allele Detail

Summary

• Symbol: Rpl24^Bst
• Name: ribosomal protein L24; belly spot and tail
• MGI ID: MGI:1856685
• Synonyms: Bst
• Gene: Rpl24 Location: Chr16:55786638-55791798 bp, + strand Genetic Position: Chr16, 33.74 cM, cytoband C1
• Alliance: Rpl24^Bst page

Rpl24^Bst/Rpl24⁺ and control

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BLKS/J

Mutation description

• Allele Type: Spontaneous (Hypomorph)
• Mutation: Intragenic deletion
• Mutation details: A 4 bp deletion disrupts the first intron branchpoint and causes abnormal splicing with retention of intron 1. The deletion removes a critical adenosine that reacts to form the lariat intermediate. PCR indicated that this is a hypomorphic allele where heterozygotes have approximately 60% of normal transcript levels and homozygotes have 20%. (J:92052)
• Inheritance: Semidominant

Disease models

Expression

In Mice Carrying this Mutation:	127 assay results
In Structures Affected by this Mutation:	20 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rpl24 Mutation: 24 strains or lines available

References

• Original: J:13703 Southard JL, et al., Bst. Mouse News Lett. 1977;56:40
• All: 26 reference(s)