Bicc1^jcpk-bpk
Spontaneous Allele Detail

Summary

• Symbol: Bicc1^jcpk-bpk
• Name: BicC family RNA binding protein 1; polycystic kidney mutation of BALB/c origin
• MGI ID: MGI:1856693
• Synonyms: bpk, jcpk/bpk
• Gene: Bicc1 Location: Chr10:70758662-70995530 bp, - strand Genetic Position: Chr10, 36.75 cM
• Alliance: Bicc1^jcpk-bpk page

Mutation origin

• Strain of Origin: BALB/c

Mutation description

• Allele Type: Spontaneous
• Mutation: Insertion
• Mutation details: The mutation in the bpk mouse was identified as a 2 base pair insertion in exon 22. This mutation is predicted to extent the length of Transcript A by 129 amino acids. Transcript B would be unaffected since the stop codon in Transcript B occurs before the mutation. (J:82707)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bicc1 Mutation: 65 strains or lines available

References

• Original: J:13276 Nauta J, et al., Renal and biliary abnormalities in a new murine model of autosomal recessive polycystic kidney disease. Pediatr Nephrol. 1993 Apr;7(2):163-72
• All: 16 reference(s)