Flt4^Chy
Chemically induced Allele Detail

Summary

• Symbol: Flt4^Chy
• Name: FMS-like tyrosine kinase 4; chylous ascites
• MGI ID: MGI:1856694
• Synonyms: Chy, Vegfr3^TKmut
• Gene: Flt4 Location: Chr11:49500506-49543566 bp, + strand Genetic Position: Chr11, 29.69 cM, cytoband A5-B1
• Alliance: Flt4^Chy page

Defective lymphatic vessels in the Flt4^Chy/Flt4⁺ mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C3H

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation resulting in the Chy phenotype is an A-to-T mutation at position 3157 resulting in an isoleucine to phenylalanine substitution at position 1053 in the tyrosine kinase domain. This mutation is located in a highly conserved catalytic domain of the receptor, in close proximity to the VEGFR-3 mutations in human primary lymphedema. In addition, the Chy mutation was shown to be allelic to an existing targeted mutation in this gene. (J:72387)
• Inheritance: Semidominant

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Flt4 Mutation: 76 strains or lines available

References

• Original: J:13981 Lyon MF, et al., Chylous ascites (Chy). Mouse News Lett. 1984;71:26
• All: 26 reference(s)