A^y
Spontaneous Allele Detail

Summary

• Symbol: A^y
• Name: nonagouti; agouti yellow
• MGI ID: MGI:1856798
• Synonyms: A(y), Ay, lethal yellow
• Gene: a Location: Chr2:154792519-154892932 bp, + strand Genetic Position: Chr2, 76.83 cM
• Alliance: A^y page

A^y/a mouse

Show the 4 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: old mutant of the mouse fancy

Mutation description

• Allele Type: Spontaneous
• Mutation: Other
• Mutation details: The A^y mutation appears to be a DNA structural alteration that disrupts a gene, hnRNP associated with lethal yellow (Raly), 5' to the agouti locus and places the agouti locus under the control of the Raly promotor. A report of recombination between A^y and the a and a^x alleles suggests that A^y was a pseudoallele of the a locus on the proximal side. However, cloning of the agouti locus and molecular analysis of a showed that the coding region of the three alleles is identical. (J:8877, J:12911, J:17512, J:18921)
• Inheritance: Semidominant

Disease models

Expression

In Mice Carrying this Mutation:	8 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	15 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying A^y

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 12 strains available Cell Lines: 0 lines available
• Carrying any a Mutation: 463 strains or lines available

References

• Original: J:12954 Dunn LC, et al., Studies on Spotting Patterns III. Interaction between Genes Affecting White Spotting and Those Affecting Color in the House Mouse. Genetics. 1937 Mar;22(2):307-18
• All: 196 reference(s)