Asp3^DBA/2J
QTL Variant Detail

Summary

• QTL variant: Asp3^DBA/2J
• Name: audiogenic seizure prone 3; DBA/2J
• MGI ID: MGI:1856807
• QTL: Asp3 Location: Chr7:27305798-36842367 bp Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: DBA/2J

Variant description

• Allele Type: QTL
• Inheritance: Recessive

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:1300

Backcross mice from (A/J x DBA/2J)F1 x A/J and (A/J x DBA/1J)F1 x A/J matings were tested for seizure susceptibility. A statistical association of susceptibility of seizures with the albino locus was indicated. The seizure susceptibility locus on Chromosome 7 is Asp3. Mice from reciprocal crosses involving these strains were tested to show that parental imprinting was not a factor in the seizure susceptibility involving Asp3.

J:43137

The asp3 locus was mapped as a quantitative trait between markers D7Mit77 and D7Mit247 in the EP (epilepsy prone) female x (EP x DBA/2J)F1 male backcross. The reciprocal backcross did not show linkage to the mouse Chromosome 7 markers, suggesting that asp3 is influenced by genetic imprinting.

References

• Original: J:11261 Neumann PE, et al., Genetic dissection of susceptibility to audiogenic seizures in inbred mice. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5408-12
• All: 2 reference(s)