cdm
Spontaneous Allele Detail

Summary

• Symbol: cdm
• Name: cadmium resistance
• MGI ID: MGI:1856816
• Gene: cdm Location: unknown Genetic Position: Chr3, Syntenic
• Alliance: cdm page

Mutation origin

• Strain of Origin: BXD2/TyJ

Mutation description

• Allele Type: Spontaneous (Not Specified)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any cdm Mutation: 0 strains or lines available

Notes

Cadmium induced this mutation.

Inbred strains differ markedly in sensitivity to cadmium-induced necrosis of the testis. Resistance is determined by homozygosity for a single recessive gene (cdm/cdm). Homozygotes show undamaged testes after a single subcutaneous dose of CdCl₂, whereas cdm/+ and +/+ mice show testes with hemorrhagic and necrotic areas. cdm is found in strains A/J, BALB/c, C3H/He, and C57BL/6; most other strains are wild-type (J:5362). The level of cadmium in testes of DBA/2 (+/+) mice 2 hours after treatment is twice as high as in C3H and BALB/c (cdm/cdm) mice. Paradoxically, the cdm/cdm resistant strains are more susceptible to the lethal effects of cadmium treatment than the +/+ susceptible strains (J:31034) and also more susceptible to the teratogenic effects of cadmium (J:6189). Induction by cadmium of metallothionein (MT) in liver of the +/+ DBA/2 strain is higher than in the cdm/cdm C3H and C57BL/6 strains. The low level in C3H appears to be due to increased rate of degradation of MT (J:7122). The difference between DBA/2 and C57BL/6 in cadmium-induced MT level is controlled by a single locus with codominant alleles that shows close linkage with cdm and may be the same locus (J:7123).

References

• Original: J:5362 Taylor BA, et al., Genetic analysis of resistance to cadmium-induced testicular damage in mice. Proc Soc Exp Biol Med. 1973 Jul;143(3):629-33
• All: 7 reference(s)