Wnt9b^clf1
Spontaneous Allele Detail

Summary

• Symbol: Wnt9b^clf1
• Name: wingless-type MMTV integration site family, member 9B; cleft lip 1
• MGI ID: MGI:1856821
• Gene: Wnt9b Location: Chr11:103618190-103640647 bp, - strand Genetic Position: Chr11, 67.47 cM
• Alliance: Wnt9b^clf1 page

Normal and Wnt9b^clf1/Wnt9b^clf1 mouse embryo

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: A/WySn

Mutation description

• Allele Type: Spontaneous
• Mutation: Insertion
• Mutation details: This mutation is a novel insertion of an IAP transposon 3' from the gene. In addition, a standard genetic test of allelism between clf1 and a Wnt9b targeted mutation demonstrated noncomplementation, showing clf1 is an allele of Wnt9b. (J:96061, J:117594)
• Inheritance: Other (see notes)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Wnt9b Mutation: 23 strains or lines available

Notes

Unequal duplicate epistasis - the normal allele at clf1 is a dominant suppressor of the recessive phenotype at clf2, and the normal allele at clf2 is a semidominant suppressor of the recessive phenotype at the clf1 locus.

References

• Original: J:22596 Juriloff DM, Major genes that cause cleft lip in mice: progress in the construction of a congenic strain and in linkage mapping. J Craniofac Genet Dev Biol Suppl. 1986;2:55-66
• All: 9 reference(s)