Foxe3^dyl
Spontaneous Allele Detail

Summary

• Symbol: Foxe3^dyl
• Name: forkhead box E3; dysgenetic lens
• MGI ID: MGI:1856851
• Synonyms: dyl
• Gene: Foxe3 Location: Chr4:114782344-114783210 bp, - strand Genetic Position: Chr4, 52.73 cM, cytoband C7
• Alliance: Foxe3^dyl page

Mutation origin

• Strain of Origin: BALB/cLiA

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: Two missense mutations in the sequences encoding the forkhead domain were shown to co-segregate with the dyl phenotype: two C-to-T transitions at coding nucleotides 277 and 293 that change codons 93 and 98 from phenylalanine to leucine and serine respectively (p.F93L, p.F98S). These mutations are in a region of the protein thought to be critical for DNA binding. (J:59880)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Foxe3 Mutation: 15 strains or lines available

References

• Original: J:6131 Sanyal S, et al., Dysgenetic lens (dyl)--a new gene in the mouse. Invest Ophthalmol Vis Sci. 1979 Jun;18(6):642-5
• All: 8 reference(s)