Ttc7^fsn
Spontaneous Allele Detail

Summary

• Symbol: Ttc7^fsn
• Name: tetratricopeptide repeat domain 7; flaky skin
• MGI ID: MGI:1856879
• Synonyms: fsn
• Gene: Ttc7 Location: Chr17:87590328-87689197 bp, + strand Genetic Position: Chr17, 57.12 cM, cytoband E4
• Alliance: Ttc7^fsn page

Mutation origin

• Strain of Origin: A/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Transposon insertion
• An ETn early transposon insertion of 183 bp occurred in intron 1`4, 57 bp upstream of exon 15. (J:97094)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

19 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ttc7^fsn

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ttc7 Mutation: 43 strains or lines available

Notes

The skin disorder is a progressive papulosquamous disease resembling some forms of human psoriasis. The cutaneous phenotype can be transferred with bone marrow grafts to Prkdc^scid homozygous mice (J:14506). Full thickness skin grafts to Foxn1^nu homozygotes retain the psoriasiform phenotype in this host lacking T cells (J:18002).
Phenotypic Similarity to Human Syndrome: Psoriasis

References

• Original: J:14506 Sundberg JP, et al., Epidermal dendritic cell populations in the flaky skin mutant mouse. Immunol Invest. 1993 Jul;22(5):389-401
• All: 25 reference(s)