Mfsd12^gr
Spontaneous Allele Detail

Summary

• Symbol: Mfsd12^gr
• Name: major facilitator superfamily domain containing 12; grizzled
• MGI ID: MGI:1856888
• Gene: Mfsd12 Location: Chr10:81193325-81202059 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Mfsd12^gr page

control and Mfsd12^gr/Mfsd12^gr

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: A x STOCK-Sgk3^fz

Mutation description

• Allele Type: Spontaneous (Null/knockout)
• Mutation: Intragenic deletion
• A spontaneous mutation deletes 9 base pairs in-frame within exon 2. (J:243759)
• Inheritance: Recessive

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Mfsd12^gr/Mfsd12^gr	involves: A * STOCK fz
cx2	Ap3d1^mh Mfsd12^+/Ap3d1^+ Mfsd12^gr	STOCK Mfsd12^gr +/+ Ap3d1^mh/J

Phenotypes:

Affected Systems	hm1		cx2
show or hide all annotated terms Sex:
craniofacial	√	√
abnormal craniofacial bone morphology	√	√
abnormal cranium morphology	√	√
abnormal jaw morphology	√	√
growth/size/body	√	√
abnormal postnatal growth/weight/body size	√	√
abnormal body weight	√	√
decreased body size	√	√
decreased body weight	√	√
integument	√	√
absent coat pigmentation	√	√
diluted coat color	√	√
limbs/digits/tail	√	√
abnormal tail morphology	√	√
kinked tail	√	√
mortality/aging	√	√
premature death	√	√
postnatal lethality, incomplete penetrance	√	√
prenatal lethality, incomplete penetrance	√	√
nervous system			√
abnormal brain theta wave pattern			√
pigmentation	√	√
absent coat pigmentation	√	√
diluted coat color	√	√
reproductive system	√
abnormal ovulation	√
decreased ovulation rate	√
skeleton	√	√
abnormal skeleton morphology	√	√
abnormal craniofacial bone morphology	√	√
abnormal cranium morphology	√	√
abnormal jaw morphology	√	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mfsd12 Mutation: 26 strains or lines available

References

• Original: J:24769 Falconer DS, Mutant stocks. Mouse News Lett. 1950;2:3
• All: 12 reference(s)