Tpst2^grt
Spontaneous Allele Detail

Summary

• Symbol: Tpst2^grt
• Name: protein-tyrosine sulfotransferase 2; growth retarded
• MGI ID: MGI:1856891
• Synonyms: grm
• Gene: Tpst2 Location: Chr5:112424557-112463227 bp, + strand Genetic Position: Chr5, 54.65 cM
• Alliance: Tpst2^grt page

Mutation origin

• Strain of Origin: DW/JMuaf

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: There is a single C-to-G mutation at coding nucleotide 840. This missense mutation leads to the replacement of a highly conserved histidine with a glutamine at codon 280 (p.H280Q) in the sulfotransferase domain. (J:122398)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Tpst2 Mutation: 106 strains or lines available

References

• Original: J:20343 Yoshida T, et al., A novel hypothyroid 'growth-retarded' mouse derived from Snell's dwarf mouse. J Endocrinol. 1994 Sep;142(3):435-46
• All: 11 reference(s)