Sox10^gt
Spontaneous Allele Detail

Summary

• Symbol: Sox10^gt
• Name: SRY (sex determining region Y)-box 10; gray tremor
• MGI ID: MGI:1856893
• Gene: Sox10 Location: Chr15:79039113-79048690 bp, - strand Genetic Position: Chr15, 37.7 cM
• Alliance: Sox10^gt page

Dilution of pheomelanin in coat hairs, white forehead blaze, white belly and feet, megacolon, vacuolation in the brain, and gliosis in mgi:1856893/mgi:1856893 mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: HYIII/LeJ

Mutation description

• Allele Type: Spontaneous (Hypomorph)
• Mutation: Single point mutation
• Mutation details: A single base-pair change (A-to-G) was identified at coding nucleotide 221 in exon 2, which changes a highly conserved glutamic acid residue in the binding domain to glycine at position 74 (p.E74G). (J:216967)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sox10 Mutation: 33 strains or lines available

References

• Original: J:13898 Sweet HO, Gray tremor (gt). Mouse News Lett. 1981;65:28
• All: 7 reference(s)