Tshr^hyt
Spontaneous Allele Detail

Summary

• Symbol: Tshr^hyt
• Name: thyroid stimulating hormone receptor; hypothyroid
• MGI ID: MGI:1856914
• Synonyms: hyt, pet, petite
• Gene: Tshr Location: Chr12:91367767-91507283 bp, + strand Genetic Position: Chr12, 44.51 cM
• Alliance: Tshr^hyt page

Mutation origin

• Strain of Origin: RF/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: The mutation in the hypothyroid mouse is a C-to-T transition at coding nucleotide 1667. This results in a substitution of proline with leucine at position 556 (p.P556L) in transmembrane domain IV of the encoded protein. (J:16854, J:26725)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tshr Mutation: 7 strains or lines available

References

• Original: J:32749 Southard JL, et al., Petite (pet). Mouse News Lett. 1977;56:41
• All: 39 reference(s)