Invs^inv
Transgenic Allele Detail

Summary

• Symbol: Invs^inv
• Name: inversin; inversion of embryonic turning
• MGI ID: MGI:1856915
• Synonyms: inv, inv^-
• Gene: Invs Location: Chr4:48279760-48431954 bp, + strand Genetic Position: Chr4, 26.11 cM, cytoband B
• Alliance: Invs^inv page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic
• Mutations: Insertion, Intragenic deletion
• Mutation details: The inv mutation was caused by a transgene insertion mutagenic event that resulted in a small duplication and a 47-kb deletion. This deletion eliminated exons 3-11, causing a frameshift in the remaining coding segment. (J:50117, J:81042)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	52 assay results
In Structures Affected by this Mutation:	36 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Invs Mutation: 60 strains or lines available

Notes

This is the only situs inversus mutation in which the asymmetries occur 100% of the time. Transgenic complementation studies demonstrated that the Invs gene alone corrects the inv mutation, and should be considered the gene responsible for the inv phenotype (J:49759, J:50117).

References

• Original: J:4934 Yokoyama T, et al., Reversal of left-right asymmetry: a situs inversus mutation [see comments]. Science. 1993 Apr 30;260(5108):679-82
• All: 37 reference(s)