Dnah11^iv
Spontaneous Allele Detail

Summary

• Symbol: Dnah11^iv
• Name: dynein, axonemal, heavy chain 11; situs inversus viscerum
• MGI ID: MGI:1856917
• Synonyms: iv
• Gene: Dnah11 Location: Chr12:117841717-118162778 bp, - strand Genetic Position: Chr12, 63.25 cM
• Alliance: Dnah11^iv page

Mutation origin

• Strain of Origin: (C3HeB/Fe x STOCK Frem2^my)F3

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A G-to-A transition mutation led to a substitution of glutamate with lysine at position 2271 (p.E2271K)in the encoded protein. This residue is located between the second and third P-loop motifs, a highly conserved region that constitutes the motor domain. (J:44093)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	101 assay results
In Structures Affected by this Mutation:	14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Dnah11 Mutation: 217 strains or lines available

References

• Original: J:24771 Hummel KP, et al., Situs Viscerum Inversus. Mouse News Lett. 1956;14:21
• All: 46 reference(s)