Nek8^jck
Spontaneous Allele Detail

Summary

• Symbol: Nek8^jck
• Name: NIMA (never in mitosis gene a)-related expressed kinase 8; juvenile cystic kidney
• MGI ID: MGI:1856919
• Synonyms: jck, Nek8-
• Gene: Nek8 Location: Chr11:78056932-78067501 bp, - strand Genetic Position: Chr11, 46.74 cM, cytoband B5
• Alliance: Nek8^jck page

Mutation origin

• Strain of Origin: C57BL/6J Tg 147-9a

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: The mutation in jck mice has been identified as a double nucleotide substitution (c.1341G>T and c.1343G>T). While c.1341G>T is a silent mutation in the last base of the leucine codon at position 447, the c.133G>T mutation in the second base of evolutionary conserved glycine codon 448 in the C-terminal domain of the protein results in it changing to valine (p.G448V). (J:79896)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nek8 Mutation: 28 strains or lines available

References

• Original: J:11885 Atala A, et al., Juvenile cystic kidneys (jck): a new mouse mutation which causes polycystic kidneys. Kidney Int. 1993 May;43(5):1081-5
• All: 30 reference(s)