Bicc1^jcpk
Chemically induced Allele Detail

Summary

• Symbol: Bicc1^jcpk
• Name: BicC family RNA binding protein 1; juvenile congenital polycystic kidney disease
• MGI ID: MGI:1856920
• Synonyms: jcpk
• Gene: Bicc1 Location: Chr10:70758662-70995530 bp, - strand Genetic Position: Chr10, 36.75 cM
• Alliance: Bicc1^jcpk page

Mutation origin

• Strain of Origin: (101 x C3H)F1

Mutation description

• Allele Type: Chemically induced (other)
• Mutation: Single point mutation
• Mutation details: This chlorambucil-induced mutation is a G to A transition in the splice acceptor site of exon 3, and results in the skipping of exon 3 and a frameshift that introduces a premature stop codon in exon 4. (J:82707)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bicc1 Mutation: 65 strains or lines available

References

• Original: J:27506 Flaherty L, et al., Chlorambucil-induced mutations in mice recovered in homozygotes. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):2859-63
• All: 9 reference(s)