Dsg4^lah
Chemically induced Allele Detail

Summary

• Symbol: Dsg4^lah
• Name: desmoglein 4; lanceolate hair
• MGI ID: MGI:1856929
• Gene: Dsg4 Location: Chr18:20569232-20604878 bp, + strand Genetic Position: Chr18, 11.35 cM
• Alliance: Dsg4^lah page

Mutation origin

• Strain of Origin: NB

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation in the lah allele was identified as an A to C transversion at nucleotide 587 within exon 6. The mutation causes a tyrosine to serine change at amino acid position 196 affecting a potential phosphorylation site. (J:83118)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Dsg4 Mutation: 86 strains or lines available

References

• Original: J:33849 Montagutelli X, et al., Lanceolate hair (lah): a recessive mouse mutation with alopecia and abnormal hair. J Invest Dermatol. 1996 Jul;107(1):20-5
• All: 3 reference(s)