Lx
Spontaneous Allele Detail

Summary

• Symbol: Lx
• Name: luxate
• MGI ID: MGI:1856944
• Gene: Lx Location: unknown Genetic Position: Chr5, Syntenic
• Alliance: Lx page

Mutation origin

• Strain of Origin: fancier's silver mouse

Mutation description

• Allele Type: Spontaneous
• Mutation: Undefined
• The luxate mutation was found in descendants of a silver mouse obtained from a fancier.
• Inheritance: Semidominant

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Lx/Lx	CBA.Cg-Lx
hm2	Lx/Lx	involves: fancier's silver mouse
ht3	Lx/Lx^+	involves: fancier's silver mouse
cx4	Dh/Dh^+ Lx/Lx^+	Not Specified

Phenotypes:

Affected Systems	hm1	hm2	ht3	cx4
show or hide all annotated terms
behavior/neurological		√
impaired limb coordination		√
hindlimb paresis		√
cardiovascular system	√
abnormal umbilical artery morphology	√
embryo	√
abnormal umbilical artery morphology	√
small hindlimb buds	√
growth/size/body		√
decreased body size		√
enlarged kidney		√
limbs/digits/tail	√	√	√	√
small hindlimb buds	√
brachypodia		√
abnormal digit morphology		√
oligodactyly		√		√
polydactyly		√	√
abnormal tarsal bone morphology		√
abnormal hindlimb morphology		√
absent femur				√
absent tibia		√		√
mortality/aging		√
postnatal lethality, incomplete penetrance		√
renal/urinary system		√
abnormal kidney morphology		√
enlarged kidney		√
hydronephrosis		√
absent kidney		√
dilated ureter		√
hydroureter		√
reproductive system		√
abnormal reproductive system morphology		√
skeleton		√		√
abnormal tarsal bone morphology		√
absent femur				√
absent tibia		√		√
abnormal pubis morphology				√
abnormal presacral vertebrae morphology		√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lx Mutation: 1 strain or line available

References

• Original: J:13039 Carter TC, The genetics of luxate mice. I. Morphological abnormalities of heterozygotes and homozygotes. J Genet. 1951;50(2):277-299
• All: 8 reference(s)