Rab23^opb
Spontaneous Allele Detail

Summary

• Symbol: Rab23^opb
• Name: RAB23, member RAS oncogene family; open brain
• MGI ID: MGI:1856980
• Synonyms: opb¹
• Gene: Rab23 Location: Chr1:33758991-33781642 bp, + strand Genetic Position: Chr1, 12.8 cM
• Alliance: Rab23^opb page

Rab23^opb/Rab23^opb embryos display neural tube closure defects, missing eyes, preaxial duplications of limbs, and detached skin

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: NMRI

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: An A-to-T mutation at coding nucleotide 115 of the encoded mRNA (c.115A>T) that altered codon 39 from a lysine to a stop codon (p.K39*). If the peptide is translated, it will lack the domains required for guanine nucleotide and Rab effector binding. (J:70423)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	70 assay results
In Structures Affected by this Mutation:	20 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rab23 Mutation: 33 strains or lines available

References

• Original: J:21617 Gunther T, et al., Open brain, a new mouse mutant with severe neural tube defects, shows altered gene expression patterns in the developing spinal cord. Development. 1994 Nov;120(11):3119-30
• All: 7 reference(s)