Summary | ||||||||
Mutation origin |
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Mutation description |
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Find Mice (IMSR) |
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Notes |
Strain differences in resistance to urethan-induced lung tumors were first noted by Cowen (J:232) who showed that the major part of the difference between the susceptible A and resistant C57BL strains was due to a single locus with susceptibility dominant.
In a more extensive analysis, Bloom and Falconer (J:13102) found the same strain distribution of susceptibility and confirmed the single-locus difference between strains A and C57BL. The recessive gene for resistance in C57BL was designated ptr (J:232). The ptr gene may be identical with the resistance allele at the Pas1 locus described by Malkinson et al. (J:8075).
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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