Fzd6^rst
Spontaneous Allele Detail

Summary

• Symbol: Fzd6^rst
• Name: frizzled class receptor 6; rosette
• MGI ID: MGI:1857024
• Gene: Fzd6 Location: Chr15:38869673-38901587 bp, + strand
• Alliance: Fzd6^rst page

Mutation origin

• Strain of Origin: English fancy stock

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A spontaneous missense mutation, c.1061G>A (AGC>ATC codon change in exon 4), results in a serine-to-isoleucine substitution at amino acid 354 of the encoded protein (p.S354I), which affects hair growth pattern. (J:340722)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fzd6 Mutation: 42 strains or lines available

Notes

Found in a strain from an English fancier. Penetrance in homozygotes appears to be complete, but expression is variable. The most common expression is two whorls, each centered on a hindleg and extending mid-dorsally and almost mid-ventrally (J:15067).

References

• Original: J:147412 Wallace ME, Rosette hair pattern (later rst). Mouse News Lett. 1968;39:18
• All: 3 reference(s)