Foxp3^sf
Spontaneous Allele Detail

Summary

• Symbol: Foxp3^sf
• Name: forkhead box P3; scurfy
• MGI ID: MGI:1857034
• Synonyms: Scurfy, sf
• Gene: Foxp3 Location: ChrX:7445915-7461482 bp, + strand Genetic Position: ChrX, 3.41 cM
• Alliance: Foxp3^sf page

Mutation origin

• Strain of Origin: STOCK MR

Mutation description

• Allele Type: Spontaneous
• Mutation: Insertion
• Mutation details: Insertion of two adenosine residues into exon 8, resulting in a 2 bp shift in the reading frame. This allele is predicted to produce a truncated protein lacking the carboxy-terminal forkhead domain. (J:66695)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

30 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 5 strains available Cell Lines: 0 lines available
• Carrying any Foxp3 Mutation: 58 strains or lines available

References

• Original: J:13126 Russell WL, et al., Exceptional inheritance of a sex-linked gene in the mouse explained on the basis that the X/O sex-chromosome constitution is female. Proc Natl Acad Sci U S A. 1959 Apr;45(4):554-560
• All: 139 reference(s)