Myo15a^sh2
Radiation induced Allele Detail

Summary

• Symbol: Myo15a^sh2
• Name: myosin XVA; shaker 2
• MGI ID: MGI:1857036
• Synonyms: sh2
• Gene: Myo15a Location: Chr11:60360165-60419195 bp, + strand Genetic Position: Chr11, 37.81 cM
• Alliance: Myo15a^sh2 page

Mutation origin

• Strain of Origin: Mixed stock

Mutation description

• Allele Type: Radiation induced
• Mutation: Single point mutation
• Mutation details: The sequences of all 49 exons of this gene were analyzed. A G to A transition was found in codon 674 within exon 18 that produces a Cys to Tyr substitution that likely removes an actin binding site. (J:48001)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Myo15a Mutation: 136 strains or lines available

Notes

The Myo15^sh2 mutation was discovered by Dobrovolskaia-Zavadskaia (J:15021) in descendants of an irradiated male.

References

• Original: J:15021 Dobrovolskaia-Zavasdkaia N, L'irradiation des testicules et l'heredite chez la souris. Arch Biol (Liege). 1928;38:457-501
• All: 37 reference(s)