Pmel^si
Spontaneous Allele Detail

Summary

• Symbol: Pmel^si
• Name: premelanosome protein; silver
• MGI ID: MGI:1857040
• Synonyms: gp100, gp87, Pmel 17, si, silver
• Gene: Pmel Location: Chr10:128540064-128556107 bp, + strand Genetic Position: Chr10, 77.13 cM
• Alliance: Pmel^si page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Spontaneous
• Mutation: Nucleotide substitutions
• Mutation details: Sequencing of partial gp87 cDNA from homozygous mutant melanocytes showed this mutation comprises a G to A substitution at base 1808, resulting in a premature stop codon and truncation of the protein in the C-terminal cystolic domain. (J:22779, J:58687)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Pmel Mutation: 38 strains or lines available

Notes

This mutation arose in an unspecified English fancy stock.

References

• Original: J:13051 Dunn LC, et al., The silver mouse, a recessive color variation. J Hered. 1930;21(12):495-498
• All: 16 reference(s)