Muc19^sld
Spontaneous Allele Detail

Summary

• Symbol: Muc19^sld
• Name: mucin 19; sublingual gland differentiation arrest
• MGI ID: MGI:1857043
• Gene: Muc19 Location: Chr15:91722531-91832440 bp, + strand Genetic Position: Chr15, 46.14 cM, cytoband E3
• Alliance: Muc19^sld page

Sublingual gland abnormalities in Muc19^tm2Culp/Muc19^tm2Culp, and Muc19^sld/Muc19^sld adults

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: NFS/N

Mutation description

Allele Type: Spontaneous (Null/knockout) Mutation: Insertion Mutation details: A spontaneous mutation inserted two CA repeats in intron 53 that results in decreased transcript stability. Additional mutations include: insertion of two GA repeats within intron 18, insertion of two T residues within intron 57 and a putative site within intron 52 of an TA repeat region that was intractable to sequencing. RT-PCR confirmed the absence of transcript expression in the sublingual gland. Inheritance: Recessive

Schematic of the spontaneous Muc19^sld mutation

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Muc19 Mutation: 41 strains or lines available

Notes

In order to be a model for Sjogren syndrome mice must be homozygous for sld and have had a thymectomy at 3 days of age (J:20364)

References

• Original: J:25317 Kojima A, New mutant: Sublingual gland differentiation arrest in the NFS/N subline. Mouse News Lett. 1988;80:147
• All: 19 reference(s)