srn
Spontaneous Allele Detail

Summary

• Symbol: srn
• Name: siren
• MGI ID: MGI:1857054
• Gene: srn Location: unknown
• Alliance: srn page

Mutation origin

• Strain of Origin: (SM/J x BUA/Hn)F3

Mutation description

• Allele Type: Spontaneous
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any srn Mutation: 0 strains or lines available

Notes

Abnormalities occur principally at the posterior end of the body and consist of absence of the hindlimbs, a single median hindlimb, or two partly fused hindlimbs, accompanied by abnormalities of the pelvic girdle, kinked or otherwise abnormal tails, atresia ani and underdeveloped intestines, and fusion and other abnormalities of the urogenital system. A small percentage of heterozygotes have twisted tails (J:5150). Craniofacial anomalies, including micrognathia, microstomia, and cleft palate, also occur in many srn/srn mice, the frequency being greater in those mice more severely affected caudally (J:6999). Homozygous embryos were first identified at 11 days of gestation by hindlimb buds postioned more ventrally than normal. At this stage there is a single median umbilical artery rather than the normal paired arteries (J:5389). In the presence of heterozygosity for the Danforth's short tail gene (Sd), which also causes caudal malformations, srn/+ heterozygotes express the siren phenotype (J:36966). Studies of recombination between srn and genes linked to Sd (since Sd/+ srn/+ double heterozygotes are often lethal) established that srn is not an allele of, nor even linked to, Sd. The modification of srn dominance by Sd is a physiological interaction (J:12037).

References

• Original: J:64443 Hoornbeek FK, srn - siren. Mouse News Lett. 1970;43:58-9
• All: 8 reference(s)