Tub^tm1Rok
Targeted Allele Detail

Summary

• Symbol: Tub^tm1Rok
• Name: TUB bipartite transcription factor; targeted mutation 1, Rosana Kapeller
• MGI ID: MGI:1857081
• Synonyms: tub-
• Gene: Tub Location: Chr7:108610087-108633666 bp, + strand Genetic Position: Chr7, 57.21 cM
• Alliance: Tub^tm1Rok page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:59994
• Parent Cell Line: MPI-71.6 (ES Cell)
• Strain of Origin: B6.129P2-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced 16 kb of sequence spanning exons 1-8. (J:59994)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tub Mutation: 37 strains or lines available

References

• Original: J:59994 Stubdal H, et al., Targeted deletion of the tub mouse obesity gene reveals that tubby is a loss-of-function mutation. Mol Cell Biol. 2000 Feb;20(3):878-82
• All: 2 reference(s)