Gpr161^vl
Spontaneous Allele Detail

Summary

• Symbol: Gpr161^vl
• Name: G protein-coupled receptor 161; vacuolated lens
• MGI ID: MGI:1857087
• Gene: Gpr161 Location: Chr1:165123358-165154314 bp, + strand Genetic Position: Chr1, 72.64 cM
• Alliance: Gpr161^vl page

Gpr161^vl/Gpr161^vl

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C3HeB/FeJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Intragenic deletion
• Mutation details: The molecular lesion is an 8-bp deletion in exon 4. This mutation is expected to cause a frameshift and premature stop codon 50 nt 3' of the deletion that results in the incorporation of 16 novel amino acids (GAHGRRTVPGTQQQHR) and truncation of the GPCR at residue 386, deleting 143 (of 203) amino acids of the C-terminal tail. An in vitro assay showed that a smaller protein can be expressed from a construct carrying this mutation and assay results suggest that internalization of the protein from the plasma membrane into the endosomal compartment is disrupted by this mutation. (J:131929)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	4 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Gpr161 Mutation: 30 strains or lines available

References

• Original: J:13464 Dickie MM, Vacuolated lens. Mouse News Lett. 1967;36:39-40
• All: 9 reference(s)