Wnt3a^vt
Spontaneous Allele Detail

Summary

• Symbol: Wnt3a^vt
• Name: wingless-type MMTV integration site family, member 3A; vestigial tail
• MGI ID: MGI:1857088
• Synonyms: vt
• Gene: Wnt3a Location: Chr11:59138859-59181578 bp, - strand Genetic Position: Chr11, 37.17 cM
• Alliance: Wnt3a^vt page

Wnt3a^vt/Wnt3a^vt

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BR

Mutation description

• Allele Type: Spontaneous (Hypomorph)
• Mutation: Undefined
• Mutation details: Examination of the Wnt3a gene by Southern blot, Northern blot on adult lung tissue and cDNA sequence analysis revealed no sign of an obvious mutation that could account for a mutant phenotype. However, this mutation and a targeted mutation, Wnt3a^tm1Amc, were demonstrated to be noncomplemeting alleles. Further evidence from whole mount in situ hybridization studies on embryos demonstrated that expression of the encoded protein is reduced in homozygous embryos, suggesting that this hypomorphic allele results from a mutation in a regulatory element. (J:31335)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	51 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Wnt3a Mutation: 26 strains or lines available

References

• Original: J:64271 Heston WE, vt - vestigial-tail. Mouse News Lett. 1951;4:11
• All: 31 reference(s)