Qki^qk-kt4
Chemically induced Allele Detail

Summary

• Symbol: Qki^qk-kt4
• Name: quaking, KH domain containing RNA binding; quaking kt4
• MGI ID: MGI:1857102
• Synonyms: Qk^qk-kt2, Qk^qk-kt3
• Gene: Qki Location: Chr17:10425480-10538706 bp, - strand Genetic Position: Chr17, 7.75 cM
• Alliance: Qki^qk-kt4 page

Mutation origin

• Strain of Origin: STOCK t^w5

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation underlying the phenotype of the Qk^kt4 mouse has been attributed to an A to G transition, resulting in a missense mutation. This results in a glutamic acid to glycine change in the QUA1 domain of the encoded protein. (J:55007)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Qki Mutation: 28 strains or lines available

Notes

This allele is homozygous lethal. This allele is presumed to be the same allele as Qk and Qk because all were recovered from the same male. qk, quaking-kt, recessive. A series of mutations induced in the quaking locus by ethylnitrosourea (ENU) have been examined. The qkk2 mutation occurred in a (C57BL/6 x CBA/Ca) F1 male. qk and qk were induced in a tw5 haplotype. These mutations are recessive embryonic lethals, but each will survive in heterozygous combination with the classic Qk mutant allele. The ENU alleles fail to complement the quaking phenotype (J:27474).

References

• Original: J:8389 Justice MJ, et al., Induction of new mutations in a mouse t-haplotype using ethylnitrosourea mutagenesis. Genet Res. 1986 Jun;47(3):187-92
• All: 3 reference(s)