Mip^Cat-Lop
Spontaneous Allele Detail

Summary

• Symbol: Mip^Cat-Lop
• Name: major intrinsic protein of lens fiber; cataract lens opacity
• MGI ID: MGI:1857105
• Gene: Mip Location: Chr10:128061707-128067681 bp, + strand Genetic Position: Chr10, 76.49 cM, cytoband D1
• Alliance: Mip^Cat-Lop page

Mutation origin

• Strain of Origin: STOCK Rb(6.15)1Ald

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A G-to-C transversion at position 151 of the encoded mRNA results in a non-conservative change at amino acid 51 from alanine to proline (p.A51P). This mutation inhibits targeting of the mutant product to the cell membrane. (J:31574)
• Inheritance: Semidominant

Disease models

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mip Mutation: 33 strains or lines available

References

• Original: J:6702 Lyon MF, et al., Lens opacity: a new gene for congenital cataract on chromosome 10 of the mouse. Genet Res. 1981 Dec;38(3):337-41
• All: 4 reference(s)