Ph
Spontaneous Allele Detail

Summary

• Symbol: Ph
• Name: patch deletion region; patch
• MGI ID: MGI:1857106
• Synonyms: Pdgfr^Ph
• Gene: Ph Location: Chr5:75315348-75330641 bp Genetic Position: Chr5, Syntenic
• Alliance: Ph page

Ph/Ph⁺

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C57BL/Gr

Mutation description

• Allele Type: Spontaneous
• Mutation: Deletion
• Ph involves 1 genes/genome features (Pdgfra) View all
• Mutation details: A deletion region including the Pdgfra gene. Precise breakpoints have not been mapped, but does not extend into the coding sequences of the adjacent Kit gene. However, expression of Kit is altered in these mutants. (J:10920, J:11255, J:23149, J:41383)
• Inheritance: Semidominant

Expression

In Mice Carrying this Mutation:	72 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ph Mutation: 1 strain or line available

Notes

Repulsion double heterozygotes of Ph and the allele Kit^W-ct at the closely linked Kit locus (Ph +/+ Kit^W-ct) are more anemic than Kit heterozygotes (+ Kit^W-ct/+ +) alone, have significantly raised leucocyte counts, and are unduly sensitive to whole body X-irradiation, indicating that the Ph locus exerts some control over hematopoiesis (J:7216). Studies of Ph homozygous embryos suggest that Ph protein is required for normal development of non-neuronal neural crest-derived structures (J:1107) and visceral endoderm and mesoderm derivatives (J:1108).

References

• Original: J:99 Gruneberg H, et al., Two closely linked genes in the mouse. Genet Res. 1960;1(1):69-90
• All: 29 reference(s)