Ace^tm1Unc
Targeted Allele Detail

Summary

• Symbol: Ace^tm1Unc
• Name: angiotensin I converting enzyme; targeted mutation 1, University of North Carolina
• MGI ID: MGI:1857115
• Synonyms: ACE-KO, stst
• Gene: Ace Location: Chr11:105858774-105880790 bp, + strand Genetic Position: Chr11, 68.84 cM
• Alliance: Ace^tm1Unc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:25284
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 14 of the gene. Exon 14 encodes amino acids critical for the normal function of both isoforms of the protein. (J:25284)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ace Mutation: 57 strains or lines available

References

• Original: J:25284 Krege JH, et al., Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature. 1995 May 11;375(6527):146-8
• All: 33 reference(s)