Ace^tm2Unc
Targeted Allele Detail

Summary

• Symbol: Ace^tm2Unc
• Name: angiotensin I converting enzyme; targeted mutation 2, University of North Carolina
• MGI ID: MGI:1857116
• Synonyms: sTsT
• Gene: Ace Location: Chr11:105858774-105880790 bp, + strand Genetic Position: Chr11, 68.84 cM
• Alliance: Ace^tm2Unc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:46177
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified isoform(s))
• Mutations: Insertion, Intragenic deletion
• Mutation details: This mutation eliminates expression of the somatic isoform of the protein but does not affect expression of the testicular isoform. A short genomic fragment extending from the beginning of exon 10 to intron 10 was replaced with a neomycin selection cassette in the oppostie transcriptional orientation to the gene. (J:46177)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Ace Mutation: 57 strains or lines available

References

• Original: J:46177 Hagaman JR, et al., Angiotensin-converting enzyme and male fertility. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2552-7
• All: 2 reference(s)