Adra2c^tm1Gsb
Targeted Allele Detail

Summary

• Symbol: Adra2c^tm1Gsb
• Name: adrenergic receptor, alpha 2c; targeted mutation 1, Gregory S Barsh
• MGI ID: MGI:1857119
• Synonyms: alpha2C-, alpha2C-ARKO, alpha2C-KO
• Gene: Adra2c Location: Chr5:35435910-35439107 bp, + strand Genetic Position: Chr5, 18.09 cM
• Alliance: Adra2c^tm1Gsb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29109
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into the single coding exon. Northern blot analysis and RT-PCR analysis did not detect functional transcript produced from this allele in homozygous mice. (J:29109, J:77486)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Adra2c Mutation: 22 strains or lines available

References

• Original: J:29109 Link RE, et al., Targeted inactivation of the gene encoding the mouse alpha 2c-adrenoceptor homolog. Mol Pharmacol. 1995 Jul;48(1):48-55
• All: 44 reference(s)