Adrb1^tm1Bkk
Targeted Allele Detail

Summary

• Symbol: Adrb1^tm1Bkk
• Name: adrenergic receptor, beta 1; targeted mutation 1, Brian K Kobilka
• MGI ID: MGI:1857120
• Synonyms: Adrb1^tm1Gsb, beta1-AR-, Beta1-KO
• Gene: Adrb1 Location: Chr19:56710549-56713582 bp, + strand Genetic Position: Chr19, 51.96 cM
• Alliance: Adrb1^tm1Bkk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:34659
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 1364 bp genomic fragment containing the initiation codon was replaced with a neomycin selection cassette. No protein product was detected on Western blots of heart tissue from homozygous mutant mice. (J:34659)

Disease models

Expression

In Mice Carrying this Mutation:	104042 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Adrb1 Mutation: 19 strains or lines available

References

• Original: J:34659 Rohrer DK, et al., Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects. Proc Natl Acad Sci U S A. 1996 Jul 9;93(14):7375-80
• All: 102 reference(s)