Agt^tm1Unc
Targeted Allele Detail

Summary

• Symbol: Agt^tm1Unc
• Name: angiotensinogen; targeted mutation 1, University of North Carolina
• MGI ID: MGI:1857121
• Synonyms: AGT-
• Gene: Agt Location: Chr8:125283326-125296445 bp, - strand Genetic Position: Chr8, 72.81 cM
• Alliance: Agt^tm1Unc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:24156
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment within exon 2 that codes for 114 amino acids of the encoded protein was replaced with a neomycin selection cassette. Radioimmunoassay tests confirmed that no protein was detectable in plasma of homozygous mice. (J:24156)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Agt Mutation: 35 strains or lines available

Notes

Human AGT and renin genes can complement the effects of the mouse null mutation (J:39934).

References

• Original: J:24156 Kim HS, et al., Genetic control of blood pressure and the angiotensinogen locus. Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2735-9
• All: 21 reference(s)