Agt^tm2Unc
Targeted Allele Detail

Summary

• Symbol: Agt^tm2Unc
• Name: angiotensinogen; targeted mutation 2, University of North Carolina
• MGI ID: MGI:1857122
• Synonyms: Agt^{TgH(Agtdup)1Unc}, Tg(Agtdup)1Unc, TgH(Agtdup)1Unc
• Gene: Agt Location: Chr8:125283326-125296445 bp, - strand Genetic Position: Chr8, 72.81 cM
• Alliance: Agt^tm2Unc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:18272
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Duplication
• Agt^tm2Unc involves 1 genes/genome features (Agt) View all
• Mutation details: A tandem duplication of the gene was created by "gap-repair" gene targeting. Radioimmunoassay tests demonstrated increased plasma levels of the encoded protein in heterozygous mice. (J:18272)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Agt Mutation: 35 strains or lines available

Notes

Human AGT and renin genes can complement the effects of the mouse null mutation (J:39934).

References

• Original: J:18272 Smithies O, et al., Targeted gene duplication and disruption for analyzing quantitative genetic traits in mice. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3612-5
• All: 7 reference(s)