Agtr2^tm1Gsb
Targeted Allele Detail

Summary

• Symbol: Agtr2^tm1Gsb
• Name: angiotensin II receptor, type 2; targeted mutation 1, Gregory S Barsh
• MGI ID: MGI:1857123
• Synonyms: AT2-KO
• Gene: Agtr2 Location: ChrX:21350863-21355072 bp, + strand Genetic Position: ChrX, 16.71 cM
• Alliance: Agtr2^tm1Gsb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:29456
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin cassette was inserted into exon 3, into sequences encoding the region after the first putative transmembrane domain of the receptor. A 209 bp segment of the coding region is also deleted. Northern blot analysis demonstrated that no transcript is produced from this allele in homozygous female or hemizygous male mice. (J:29456)

Expression

In Mice Carrying this Mutation:	55 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Agtr2 Mutation: 11 strains or lines available

References

• Original: J:29456 Hein L, et al., Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. Nature. 1995 Oct 26;377(6551):744-7
• All: 36 reference(s)