Apoc3^tm1Unc
Targeted Allele Detail

Summary

• Symbol: Apoc3^tm1Unc
• Name: apolipoprotein C-III; targeted mutation 1, University of North Carolina
• MGI ID: MGI:1857128
• Synonyms: apoc3-
• Gene: Apoc3 Location: Chr9:46144348-46146934 bp, - strand Genetic Position: Chr9, 25.36 cM
• Alliance: Apoc3^tm1Unc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:21750
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A genomic fragment containing exon 4 was replaced with a neomycin selection cassette. Northern blot analysis indicated that no stable transcript was produced from this allele in homozygous mice. Expression of the Apoa1 and Apoa4 genes that lie in close proximity to Apoc3 are reduced by half in the intestine of homozygotes but not in the liver. (J:21750)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Apoc3 Mutation: 19 strains or lines available

References

• Original: J:21750 Maeda N, et al., Targeted disruption of the apolipoprotein C-III gene in mice results in hypotriglyceridemia and protection from postprandial hypertriglyceridemia. J Biol Chem. 1994 Sep 23;269(38):23610-6
• All: 14 reference(s)