Asgr2^tm1Her
Targeted Allele Detail

Summary

• Symbol: Asgr2^tm1Her
• Name: asialoglycoprotein receptor 2; targeted mutation 1, Joachim Herz
• MGI ID: MGI:1857130
• Synonyms: ASGP-R2^-, HL-2 -
• Gene: Asgr2 Location: Chr11:69983470-69997013 bp, + strand Genetic Position: Chr11, 42.99 cM
• Alliance: Asgr2^tm1Her page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:21380
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 2. Northern blot analysis demonstrated that the transcript was not detectable in liver RNA from homozygous mice. The protein was also not detected in liver membrane protein fractions derived from homozygous mice. (J:21380)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Asgr2 Mutation: 20 strains or lines available

References

• Original: J:21380 Ishibashi S, et al., Asialoglycoprotein receptor deficiency in mice lacking the minor receptor subunit. J Biol Chem. 1994 Nov 11;269(45):27803-6
• All: 9 reference(s)